Hypoxic reperfusion of the ischemic heart and oxygen radical generation.

@article{Angelos2006HypoxicRO,
  title={Hypoxic reperfusion of the ischemic heart and oxygen radical generation.},
  author={Mark G. Angelos and Vijay Kumar Kutala and Carlos A. D. Torres and Guanglong He and Jason D Stoner and Marwan Mohammad and Periannan Kuppusamy},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 1},
  pages={H341-7}
}
Postischemic myocardial contractile dysfunction is in part mediated by the burst of reactive oxygen species (ROS), which occurs with the reintroduction of oxygen. We hypothesized that tissue oxygen tension modulates this ROS burst at reperfusion. After 20 min of global ischemia, isolated rat hearts were reperfused with temperature-controlled (37.4 degrees C) Krebs-Henseleit buffer saturated with one of three different O2 concentrations (95, 20, or 2%) for the first 5 min of reperfusion and then… CONTINUE READING
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