Hypoxic regulation of Ca2+ signaling in cultured rat astrocytes.

  title={Hypoxic regulation of Ca2+ signaling in cultured rat astrocytes.},
  author={Ian F Smith and John P Boyle and Peng Kang and Sophie Rome and Hugh A Pearson and Christopher S. Peers},
  volume={49 1},
Acute hypoxia modulates various cell processes, such as cell excitability, through the regulation of ion channel activity. Given the central role of Ca2+ signaling in the physiological functioning of astrocytes, we have investigated how acute hypoxia regulates such signaling, and compared results with those evoked by bradykinin (BK), an agonist whose ability to liberate Ca2+ from intracellular stores is well documented. In Ca2+-free perfusate, BK evoked rises of [Ca2+]i in all cells examined… CONTINUE READING
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