Hypoxic pulmonary vasoconstriction and gas exchange in acute canine pulmonary embolism.

@article{Delcroix1996HypoxicPV,
  title={Hypoxic pulmonary vasoconstriction and gas exchange in acute canine pulmonary embolism.},
  author={Marion Delcroix and Christian M{\'e}lot and Françoise Vermeulen and Robert Naeije},
  journal={Journal of applied physiology},
  year={1996},
  volume={80 4},
  pages={1240-8}
}
Hypoxic pulmonary vasoconstriction (HPV) is inhibited in several models of acute lung injury. Whether HPV is preserved in pulmonary embolism is unknown. We investigated the effects of a reduction in the fraction of inspired O2 (FIO2) on pulmonary hemodynamics and gas exchange in anesthetized dogs before and after autologous blood clot pulmonary embolism. In a first group of 14 dogs, stimulus-response curves for HPV were constructed as pulmonary arterial pressure (Ppa) vs. FIO2 varied between 1… CONTINUE READING

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