Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels

@article{Sweeney2000HypoxicPV,
  title={Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels},
  author={Michele A Sweeney and Jason X-J Yuan},
  journal={Respiratory Research},
  year={2000},
  volume={1},
  pages={40 - 48}
}
Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in PASMCs, inducing membrane depolarization and a rise in [Ca2+ ]cyt that triggers vasoconstriction. Prolonged hypoxia inhibits expression of Kv channels and reduces Kv channel currents in PASMCs. The consequent membrane depolarization raises [Ca2… CONTINUE READING

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