Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation.

@article{Zhang2007HypoxicPP,
  title={Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation.},
  author={Yunhong Zhang and Tae Sung Park and Jeffrey M. Gidday},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 6},
  pages={H2573-81}
}
Preconditioning-induced ischemic tolerance is well documented in the brain, but cell-specific responses and mechanisms require further elucidation. The aim of this study was to develop an in vitro model of ischemic tolerance in human brain microvascular endothelial cells (HBMECs) and to examine the roles of phosphatidylinositol 3-kinase (PI3-kinase)/Akt and the inhibitor-of- apoptosis protein, survivin, in the ability of hypoxic preconditioning (HP) to protect endothelium from apoptotic cell… CONTINUE READING
50 Citations
63 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Similar Papers

Loading similar papers…