Hypoxic preconditioning protects against ischemic brain injury

  title={Hypoxic preconditioning protects against ischemic brain injury},
  author={Frank R. Sharp and Ruiqiong Ran and Aigang Lu and Yang Tang and Kenneth I. Strauss and Todd F. Glass and Tim Ardizzone and Myriam Bernaudin},
Animals exposed to brief periods of moderate hypoxia (8% to 10% oxygen for 3 hours) are protected against cerebral and cardiac ischemia between 1 and 2 days later. This hypoxia preconditioning requires new RNA and protein synthesis. The mechanism of this hypoxia-induced tolerance correlates with the induction of the hypoxia-inducible factor (HIF), a transcription factor heterodimeric complex composed of inducible HIF-1α and constitutive HIF-1β proteins that bind to the hypoxia response elements… CONTINUE READING


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