Hypoxic preconditioning protects against ischemic brain injury

@article{Sharp2004HypoxicPP,
  title={Hypoxic preconditioning protects against ischemic brain injury},
  author={Frank R. Sharp and Ruiqiong Ran and Aigang Lu and Yang Tang and Kenneth I. Strauss and Todd F. Glass and Tim Ardizzone and Myriam Bernaudin},
  journal={NeuroRX},
  year={2004},
  volume={1},
  pages={26-35}
}
Animals exposed to brief periods of moderate hypoxia (8% to 10% oxygen for 3 hours) are protected against cerebral and cardiac ischemia between 1 and 2 days later. This hypoxia preconditioning requires new RNA and protein synthesis. The mechanism of this hypoxia-induced tolerance correlates with the induction of the hypoxia-inducible factor (HIF), a transcription factor heterodimeric complex composed of inducible HIF-1α and constitutive HIF-1β proteins that bind to the hypoxia response elements… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 100 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 173 references

Hypoxia-inducible factor and its biomedical relevance.

The Journal of biological chemistry • 2003
View 10 Excerpts
Highly Influenced

Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 5 Excerpts
Highly Influenced

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.

Trends in molecular medicine • 2001
View 5 Excerpts
Highly Influenced

Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K SHARP ET AL

C Heurteaux, I Lauritzen, C Widmann, M. Lazdunski
NeuroRx , • 2004

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, HYPOXIA-INDUCED TOLERANCE

T Kamura, S Sato, +4 authors JW. Conaway
NeuroRx , • 2004

Von Hippel-Lindau disease.

Current molecular medicine • 2004
View 1 Excerpt

Similar Papers

Loading similar papers…