Hypoxic preconditioning increases iron transport rate in astrocytes.

  title={Hypoxic preconditioning increases iron transport rate in astrocytes.},
  author={Lei Yang and Ming Fan and Fang Du and Qi Gong and Zheng Gang Bi and Zhou Zhu and Ling Ling Zhu and Ya Ke},
  journal={Biochimica et biophysica acta},
  volume={1822 4},
The mechanisms involved in the neuroprotection induced by hypoxic preconditioning (HP) have not been fully elucidated. The involvement of hypoxia-inducible factor-1 alpha (HIF-1alpha) in such neuroprotection has been confirmed. There is also evidence showing that a series of genes with important functions in iron metabolism, including transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1), are regulated by HIF-1alpha in response to hypoxia in extra-neural organs or cells. We… CONTINUE READING