Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD

Abstract

A defective induction of epithelial autophagy may have a role in the pathogenesis of inflammatory bowel diseases. This process is regulated mainly by extracellular factors such as nutrients and growth factors and is highly induced by diverse situations of stress. We hypothesized that epithelial autophagy is regulated by the immune response that in turn is… (More)
DOI: 10.1038/mi.2013.108

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