Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells.

  title={Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells.},
  author={Yoshimitsu Takahashi and Shigeru Takahashi and Yutaka Shiga and Tatsuya Yoshimi and Takumi Miura},
  journal={The Journal of biological chemistry},
  volume={275 19},
Accumulated evidence indicates that hypoxia activates collagen synthesis in tissues. To explore the molecular mechanism of activation, we screened genes that are up-regulated or down-regulated by hypoxia. Fibroblasts isolated from fetal rat lung were cultured under hypoxia. Differential display technique showed that the mRNA level of prolyl 4-hydroxylase (PH) alpha(I), an active subunit that catalyzes the oxygen-dependent hydroxylation of proline residue in procollagen, increased 2-3-fold after… CONTINUE READING


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