Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1.

@article{Bae2006HypoxicIO,
  title={Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1.},
  author={S D Bae and Su-Ryun Kim and Jong Gab Kim and Jee Yeon Kim and Tae Hyeon Koo and Hye-Ock Jang and Il Dong Yun and Mi-Ae Yoo and M A Bae},
  journal={FEBS letters},
  year={2006},
  volume={580 17},
  pages={4105-13}
}
Visfatin has been originally identified as a growth factor for early stage B cells and recently known as an adipokine. Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells. We also demonstrate that induction of visfatin gene is regulated by hypoxia-inducible factor-1alpha (HIF-1alpha). Moreover, 5'-flanking promoter region of human visfatin gene contains two functional HIF responsive elements (HREs), activating the expression of visfatin… CONTINUE READING

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