Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation.

@article{Evans2001HypoxicHI,
  title={Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation.},
  author={Sydney M Evans and Stephen M. Hahn and Deirdre P Magarelli and Cameron J. Koch},
  journal={American journal of clinical oncology},
  year={2001},
  volume={24 5},
  pages={467-72}
}
We evaluated the levels and distribution of hypoxia in 31 human tumors using fluorescent immunohistochemical detection of binding by the 2-nitroimidazole, EF5. Hypoxia was found to be a heterogeneous property of human tumors. Necrosis was usually found adjacent to the highest level of binding in an individual patient's tumor. However, hypoxia often occurred without necrosis. In the group of tumors studied, the most common relationship between blood vessels (PECAM/CD31) and EF5 staining was… CONTINUE READING

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