Hypoxic expansion promotes the chondrogenic potential of articular chondrocytes.

  title={Hypoxic expansion promotes the chondrogenic potential of articular chondrocytes.},
  author={Rainer Josef Egli and J D Bastian and Reinhold Ganz and Willy Hofstetter and Michael Leunig},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={26 7},
For cell-based cartilage repair strategies, an ex vivo expansion phase is required to obtain sufficient numbers of cells needed for therapy. Although recent reports demonstrated the central role of oxygen for the function and differentiation of chondrocytes, a beneficial effect of low oxygen concentrations during the expansion of the cells to further improve their chondrogenic capacity has not been investigated.Therefore, freshly harvested bovine articular chondrocytes were grown in two… CONTINUE READING

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