Hypoxic exercise training causes erythrocyte senescence and rheological dysfunction by depressed Gardos channel activity.

@article{Mao2011HypoxicET,
  title={Hypoxic exercise training causes erythrocyte senescence and rheological dysfunction by depressed Gardos channel activity.},
  author={Tso-Yen Mao and Li-Lan Fu and Jong Shyan Wang},
  journal={Journal of applied physiology},
  year={2011},
  volume={111 2},
  pages={
          382-91
        }
}
Despite enhancing cardiopulmonary and muscular fitness, the effect of hypoxic exercise training (HE) on hemorheological regulation remains unclear. This study investigates how HE modulates erythrocyte rheological properties and further explores the underlying mechanisms in the hemorheological alterations. Twenty-four sedentary males were randomly divided into hypoxic (HE; n = 12) and normoxic (NE; n = 12) exercise training groups. The subjects were trained on 60% of maximum work rate under 15… 
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Methods Citations
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The HET still facilitated global aggregation after HE because of the augmented fibrinogen-related factors, even though the intrinsic factor was suppressed, and HE further led to erythrocyte senescence.
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The results of this study show that, living (LHC) and training at altitude (LHTH) seems more advantageous in hemorheological point of view.
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Absolute hypoxic exercise training enhances in vitro thrombin generation by increasing procoagulant platelet-derived microparticles under high shear stress in sedentary men.
TLDR
It is concluded that both HRT and NT depress similarly HS-mediated TG during exercise, but HAT accelerates the prothrombotic response to vigorous exercise, providing new insights into how exercise training under a hypoxic condition influences the risk of thrombosis associated with stenosis.
Effects of acute and chronic hematocrit modulations on blood viscosity in endurance athletes.
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While acute increase in Hct during exercise caused an increase of blood viscosity, the chronic increase of Hct induced by training session did not result in a rise in blood visCosity, suggesting the lowering of plasma viscosities during training may compensate for the increase ofHct, hence limiting its impact on blood vis Coscosity.
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