Hypoxic control of metastasis

  title={Hypoxic control of metastasis},
  author={Erinn B. Rankin and Amato J. Giaccia},
Metastatic disease is the leading cause of cancer-related deaths and involves critical interactions between tumor cells and the microenvironment. Hypoxia is a potent microenvironmental factor promoting metastatic progression. Clinically, hypoxia and the expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are associated with increased distant metastasis and poor survival in a variety of tumor types. Moreover, HIF signaling in malignant cells influences multiple steps within… CONTINUE READING
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  • G. L. Semenza
  • Biophys. Acta
  • 1863

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