Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.

@article{Schroedl2002HypoxicBN,
  title={Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.},
  author={Clara J Schroedl and David S. McClintock and G R Scott Budinger and Navdeep S Chandel},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 5},
  pages={L922-31}
}
The molecular mechanisms by which cells detect hypoxia (1.5% O2), resulting in the stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) protein remain unclear. One model proposes that mitochondrial generation of reactive oxygen species is required to stabilize HIF-1alpha protein. Primary evidence for this model comes from the observation that cells treated with complex I inhibitors, such as rotenone, or cells that lack mitochondrial DNA (rho(0)-cells) fail to generate reactive oxygen… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 97 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Reactive oxygen species generated at mitochondrial complex III stabilize L930 HIF-1 STABILIZATION DURING HYPOXIA AND ANOXIA AJP-Lung Cell Mol Physiol

  • NS Chandel, DS McClintock, +4 authors PT. Schumacker
  • J Biol Chem
  • 2002
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…