Hypoxic and posthypoxic responses in isolated coronary arteries and veins: role of endothelium.

In isolated porcine and canine coronary artery and vein short-lasting exposure (8 min) to hypoxia (pO2 less than 20 mm Hg) evoked an increase of tone (6-34% of maximum contraction to potassium chloride). In arterial preparations of both species this response was significantly more pronounced in endothelium-intact vessels as compared to rubbed ones… CONTINUE READING