Hypoxic Tumor Cells Promoter of Vascular Endothelial Growth Factor Gene against Therapeutic Efficacy of the Suicide Gene Driven by the Updated

Abstract

We examined whether herpes simplex virus thymidine kinase (HSVTK) gene expression driven by the promoter of the vascular endothelial growth factor (VEGF) gene that is activated by hypoxia is effective in killing highly metastatic Lewis lung carcinoma A11 cells under hypoxic conditions. We isolated the promoter region encompassing the hypoxia response… (More)

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