Hypoxic Signaling During Tissue Repair and Regenerative Medicine

  title={Hypoxic Signaling During Tissue Repair and Regenerative Medicine},
  author={Tessa D. Nauta and Victor W. M. van Hinsbergh and Pieter Koolwijk},
  booktitle={International journal of molecular sciences},
In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α). Even though much is known about the function of HIF-1α in… CONTINUE READING
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