Hypoxic Culture Promotes Dopaminergic-Neuronal Differentiation of Nasal Olfactory Mucosa Mesenchymal Stem Cells via Upregulation of Hypoxia-Inducible Factor-1α

@inproceedings{Zhuo2017HypoxicCP,
  title={Hypoxic Culture Promotes Dopaminergic-Neuronal Differentiation of Nasal Olfactory Mucosa Mesenchymal Stem Cells via Upregulation of Hypoxia-Inducible Factor-1α},
  author={Yi Zhi Zhuo and Lei E. Wang and Lite Ge and Xuan Li and Da Duan and Xiaohua Teng and Miao Jiang and Kai Liu and Ting Yuan and Pei Chih Wu and Hao Wang and Yujia Deng and Huali Xie and Ping Chen and Ying Xia and Ming Lu},
  booktitle={Cell transplantation},
  year={2017}
}
Olfactory mucosa mesenchymal stem cells (OM-MSCs) display significant clonogenic activity and may be easily propagated for Parkinson's disease therapies. Methods of inducing OM-MSCs to differentiate into dopaminergic (DAergic) neurons using olfactory ensheathing cells (OECs) are thus an attractive topic of research. We designed a hypoxic induction protocol to generate DAergic neurons from OM-MSCs using a physiological oxygen (O2) level of 3% and OEC-conditioned medium (OCM; HI group). The… CONTINUE READING
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