Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells

  title={Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells},
  author={Marica Vaapil and Karolina Helczynska and Ren{\'e} Villadsen and Ole William Petersen and Elisabet Johansson and Siv Beckman and Christer Larsson and Sven P{\aa}hlman and Annika J{\"o}gi},
  booktitle={PloS one},
INTRODUCTION Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially… CONTINUE READING
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Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer

  • K Helczynska, AM Larsson, L Holmquist Mengelbier, E Bridges, E Fredlund
  • Cancer Res
  • 2008
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