Hypoxia. 5. Hypoxia and hematopoiesis.

@article{Yoon2011Hypoxia5H,
  title={Hypoxia. 5. Hypoxia and hematopoiesis.},
  author={Donghoon Yoon and Prem Ponka and Josef T. Prchal},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={300 6},
  pages={
          C1215-22
        }
}
Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia. HIF-1 and HIF-2 regulate many genes that are involved in erythropoiesis and iron metabolism, which are essential for tissue oxygen delivery. 
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Hypoxia-Inducible Factors in Physiology and Medicine
Interaction between PARP-1 and HIF-2α in the hypoxic response
TLDR
A complex functional interaction between PARP-1 and the HIF system is revealed and it is suggested that parp-1 is involved in the fine tuning of the Hif-mediated hypoxic response in vivo.
Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer
TLDR
The biochemical importance of hypoxia-inducible factors cannot be overemphasized as carcinogenesis, cancer progression, and Hifs are intricately linked and also the prospects of HIFs as an alternative source of cancer therapies are highlighted.
Tissue Hypoxia: Implications for the Respiratory Clinician
TLDR
Clinical management of tissue hypoxia usually focuses on global hypoxemia and oxygen delivery, but this focus needs to change to assessing and managing mission-critical regional Hypoxia to avoid unnecessary and potential toxic global strategies.
Oxygen Sensing and Homeostasis.
TLDR
This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.
Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery.
  • G. Semenza
  • Biology
    American journal of physiology. Cell physiology
  • 2011
TLDR
HIF and MCM proteins act in a mutually antagonistic manner, providing a novel molecular mechanism for homeostatic regulation of cell proliferation based on the relative levels of these proteins.
Erythropoiesis: from molecular pathways to system properties.
TLDR
It is shown that three Epo-regulated erythroblast survival pathways each give rise to distinct system properties, and that signal transduction by Stat5 combines binary and graded modalities, thereby increasing signaling fidelity over the wide dynamic range of Epo found in health and disease.
HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo.
TLDR
Evidence is provided that HIF-1 limits differentiation of precursors into plasmacytoid dendritic cells (pDCs) in wild-type mice and that the low oxygen content in the bone marrow might limit pDC development.
Erythrocytosis and Pulmonary Hypertension in a Mouse Model of Human HIF2A Gain of Function Mutation*
TLDR
These findings firmly establish missense mutations in HIF-2α as a cause of erythrocytosis, highlight the importance of this Hif-α isoform in erythropoiesis, and point to physiologic consequences of HIF -2α dysregulation.
Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.
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