Hypoxia. 2. Hypoxia regulates cellular metabolism.

@article{Wheaton2011Hypoxia2H,
  title={Hypoxia. 2. Hypoxia regulates cellular metabolism.},
  author={William W. Wheaton and Navdeep S Chandel},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={300 3},
  pages={C385-93}
}
Adaptation to lowering oxygen levels (hypoxia) requires coordinated downregulation of metabolic demand and supply to prevent a mismatch in ATP utilization and production that might culminate in a bioenergetic collapse. Hypoxia diminishes ATP utilization by downregulating protein translation and the activity of the Na-K-ATPase. Hypoxia diminishes ATP production in part by lowering the activity of the electron transport chain through activation of the transcription factor hypoxia-inducible factor… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 115 references

Activating transcription factor 4 is translationally regulated by hypoxic stress.

Molecular and cellular biology • 2004
View 4 Excerpts
Highly Influenced

Themes C392 HYPOXIA AND METABOLISM AJP-Cell Physiol

M Schneider, K Van Geyte, +14 authors J Weitz
Gastroenterology 138: 1143–1154, • 2011
View 1 Excerpt

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