Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach

@inproceedings{Schmidt2017HypoxiaTL,
  title={Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach},
  author={Hanno Schmidt and Assaf Malik and Anne Bicker and Gesa Poetzsch and Aaron Avivi and Imad Shams and Thomas Hankeln},
  booktitle={Scientific Reports},
  year={2017}
}
The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from normoxic and hypoxic Spalax and rat liver tissue. Hypoxic Spalax broadly downregulates genes from major liver function pathways. This energy-saving response is likely a crucial adaptation to low oxygen levels. In contrast, the hypoxia… CONTINUE READING
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