Hypoxia suppresses the production of MMP-9 by human monocyte-derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway.

@article{Zhao2008HypoxiaST,
  title={Hypoxia suppresses the production of MMP-9 by human monocyte-derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway.},
  author={Peng Zhao and Xin-Gang Li and Meixiang Yang and Qianqian Shao and Donghai Wang and Shuxun Liu and Haibo Song and Bingfeng Song and Yan Zhang and Xun Qu},
  journal={Molecular immunology},
  year={2008},
  volume={45 8},
  pages={2187-95}
}
The migration of dendritic cells (DCs) from the site of antigen-encounter to regional lymphoid organs is crucial for DCs to function as potent antigen-presenting cells. Matrix metalloproteinase-9 (MMP-9) is critically for DCs migration across extracellular matrix (ECM). We verified in previous studies that hypoxia diminished the production of MMP-9 in human monocyte-derived DCs via an unknown mechanism. In this study, we found, for the first time to our knowledge, that hypoxia altered the… CONTINUE READING

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