Hypoxia suppresses conversion from proliferative arrest to cellular senescence.

@article{Leontieva2012HypoxiaSC,
  title={Hypoxia suppresses conversion from proliferative arrest to cellular senescence.},
  author={Olga V. Leontieva and Venkatesh Natarajan and Zoya N. Demidenko and Lyudmila G. Burdelya and Andrei V. Gudkov and Mikhail V. Blagosklonny},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 33},
  pages={13314-8}
}
Unlike reversible quiescence, cellular senescence is characterized by a large flat cell morphology, β-gal staining and irreversible loss of regenerative (i.e., replicative) potential. Conversion from proliferative arrest to irreversible senescence, a process named geroconversion, is driven in part by growth-promoting pathways such as mammalian target of… CONTINUE READING