Hypoxia supports reprogramming of mesenchymal stromal cells via induction of embryonic stem cell-specific microRNA-302 cluster and pluripotency-associated genes.

@article{Foja2013HypoxiaSR,
  title={Hypoxia supports reprogramming of mesenchymal stromal cells via induction of embryonic stem cell-specific microRNA-302 cluster and pluripotency-associated genes.},
  author={Sabine Foja and Matthias T. Jung and Bernadette Harwardt and Dagmar Riemann and Oliver Pelz-Ackermann and Insa S. Schroeder},
  journal={Cellular reprogramming},
  year={2013},
  volume={15 1},
  pages={68-79}
}
Pluripotency is characterized by specific transcription factors such as OCT4, NANOG, and SOX2, but also by pluripotency-associated microRNAs (miRs). Somatic cells can be reprogrammed by forced expression of these factors leading to induced pluripotent stem cells (iPSCs) with characteristics similar to embryonic stem cells (ESCs). However, current reprogramming strategies are commonly based on viral delivery of the pluripotency-associated factors, which affects the integrity of the genome and… CONTINUE READING

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