Hypoxia stimulates osteoclast formation from human peripheral blood.

  title={Hypoxia stimulates osteoclast formation from human peripheral blood.},
  author={Jennifer C Utting and Adrienne Margaret Flanagan and Andrea Brandao-Burch and Isabel R Orriss and Timothy Arnett},
  journal={Cell biochemistry and function},
  volume={28 5},
Active pathological bone destruction in humans often occurs in locations where oxygen tension (pO(2)) is likely to be low, for example, at the sites of tumours, inflammation, infections and fractures, or the poorly vascularized yellow fatty marrow of the elderly. We examined the effect of pO(2) on formation of osteoclasts, the cells responsible for bone resorption, in 14-day cultures of normal human peripheral blood mononuclear cells (hPBMCs) on ivory discs. Hypoxia (1-2% O(2)) caused threefold… CONTINUE READING

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