Hypoxia stimulates osteoclast formation from human peripheral blood.

@article{Utting2010HypoxiaSO,
  title={Hypoxia stimulates osteoclast formation from human peripheral blood.},
  author={Jennifer C Utting and Adrienne Margaret Flanagan and Andrea Brandao-Burch and Isabel R Orriss and Timothy Arnett},
  journal={Cell biochemistry and function},
  year={2010},
  volume={28 5},
  pages={374-80}
}
Active pathological bone destruction in humans often occurs in locations where oxygen tension (pO(2)) is likely to be low, for example, at the sites of tumours, inflammation, infections and fractures, or the poorly vascularized yellow fatty marrow of the elderly. We examined the effect of pO(2) on formation of osteoclasts, the cells responsible for bone resorption, in 14-day cultures of normal human peripheral blood mononuclear cells (hPBMCs) on ivory discs. Hypoxia (1-2% O(2)) caused threefold… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 42 references

Regulation of vascularization by hypoxia-inducible factor 1.

Annals of the New York Academy of Sciences • 2009
View 1 Excerpt

perfusion in proximal femur of subjects with decreased bone mineral density preferentially affects the femoral neck

JC Utting, SP Robins, +3 authors TR Arnett
2009

Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration.

Proceedings of the National Academy of Sciences of the United States of America • 2008

Compromised bone marrow perfusion in osteoporosis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2008
View 1 Excerpt

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