Hypoxia stimulates inflammatory and fibrotic responses from nasal-polyp derived fibroblasts.

@article{Early2007HypoxiaSI,
  title={Hypoxia stimulates inflammatory and fibrotic responses from nasal-polyp derived fibroblasts.},
  author={S Brandon Early and Kathleen Hise and Joseph K. Han and Larry C Borish and John W. Steinke},
  journal={The Laryngoscope},
  year={2007},
  volume={117 3},
  pages={511-5}
}
OBJECTIVES/HYPOTHESIS Chronic sinusitis is primarily an inflammatory disorder characterized by hyperplasia of immune cells and sinus tissue. Nasal mucosal swelling or polyps can occlude the sinus ostia, decreasing the level of oxygen available to the sinus tissue. Hypoxia in many diseases results in increased recruitment of inflammatory cells and release of cytokines. The role of hypoxia in chronic sinusitis is unknown. We hypothesized that hypoxia induces production of mediators that recruit… CONTINUE READING