Hypoxia stimulates cytokine production by villous explants from the human placenta.

@article{Benyo1997HypoxiaSC,
  title={Hypoxia stimulates cytokine production by villous explants from the human placenta.},
  author={Dr. Ahmed Ali Fadul Benyo and Theresa M Miles and Kirk P. Conrad},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 5},
  pages={1582-8}
}
It has been hypothesized that inadequate placentation in the hypertensive disorder of pregnancy known as preeclampsia creates foci of placental ischemia/hypoxia leading to the elaboration of factors that compromise systemic endothelial function to produce disease sequelae. As tumor necrosis factor-alpha (TNF alpha) and interleukin-1 (IL-1) are inflammatory cytokines capable of eliciting endothelial cell dysfunction, we investigated whether the production of these inflammatory cytokines by… CONTINUE READING
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