Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages.

@article{Bosco2004HypoxiaSI,
  title={Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages.},
  author={Maria Carla Bosco and Maura Puppo and Sandra Pastorino and Zenghui Mi and Giovanni Melillo and Stefano Massazza and Annamaria Rapisarda and Luigi Varesio},
  journal={Journal of immunology},
  year={2004},
  volume={172 3},
  pages={1681-90}
}
Hypoxia, a local decrease in oxygen tension occurring in inflammatory and tumor lesions, modulates gene expression in macrophages. Because macrophages are important chemokine producers, we investigated the regulatory effects of hypoxia on macrophage-derived chemokines. We demonstrated that hypoxia inhibits the production of the macrophage and T lymphocyte chemotactic and activating factor, monocyte chemoattractant protein-1 (MCP-1). Exposure of mouse macrophages to low oxygen tension resulted… CONTINUE READING

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