Hypoxia-reoxygenation induces premature senescence in FA bone marrow hematopoietic cells.

@article{Zhang2005HypoxiareoxygenationIP,
  title={Hypoxia-reoxygenation induces premature senescence in FA bone marrow hematopoietic cells.},
  author={Xiaoling Zhang and June Li and Daniel P. Sejas and Q. Pang},
  journal={Blood},
  year={2005},
  volume={106 1},
  pages={
          75-85
        }
}
Hematopoietic cells are often exposed to transient hypoxia and reoxygenation as they develop and migrate. Given that bone marrow (BM) failure occurred in patients with Fanconi anemia (FA), we reason that hypoxia-then-reoxygenation represents a physiologically relevant stress for FA hematopoietic progenitor/stem cells. Here we show that expansion of Fancc-/- BM cells enriched for progenitor and stem cells was significantly decreased after 2 continuous cycles of hyperoxic-hypoxic-hyperoxic… Expand
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