Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis.

@article{Chakraborty2006HypoxiaRC,
  title={Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis.},
  author={Goutam Chakraborty and Hema Rangaswami and Sidharth Jain and Gopal C. Kundu},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 16},
  pages={
          11322-31
        }
}
Hypoxia is a key parameter that controls tumor angiogenesis and malignant progression by regulating the expression of several oncogenic molecules. The nonreceptor protein-tyrosine kinases Syk and Lck play crucial roles in the signaling mechanism of various cellular processes. The enhanced expression of Syk in normal breast tissue but not in malignant breast carcinoma has prompted us to investigate its potential role in mammary carcinogenesis. Accordingly, we hypothesized that hypoxia… CONTINUE READING

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THE EFFECT OF SYK ON BREAST CANCER PROGRESSION

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