Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model.

@article{Glunde2008HypoxiaRC,
  title={Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model.},
  author={Kristine Glunde and Tariq Shah and Paul T. Winnard and Venu Raman and Tomoyo Takagi and F. Vesuna and Dmitri Artemov and Zaver M. Bhujwalla},
  journal={Cancer research},
  year={2008},
  volume={68 1},
  pages={172-80}
}
The intensity of the total choline (tCho) signal in spectroscopic images of tumors is spatially heterogeneous. The likewise heterogeneous physiologic tumor microenvironment may contribute to this heterogeneity. We therefore investigated the relationship between hypoxia, choline metabolites, and choline kinase (Chk) in a human prostate cancer model. Human PC-3 prostate cancer cells were engineered to express enhanced green fluorescent protein (EGFP) under hypoxic conditions. These PC-3-5HRE-EGFP… CONTINUE READING

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