Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

  title={Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.},
  author={M. P. Deyoung and P. Hor{\'a}k and A. Sofer and D. Sgroi and L. Ellisen},
  journal={Genes & development},
  volume={22 2},
  • M. P. Deyoung, P. Horák, +2 authors L. Ellisen
  • Published 2008
  • Biology, Medicine
  • Genes & development
  • Hypoxia induces rapid and dramatic changes in cellular metabolism, in part through inhibition of target of rapamycin (TOR) kinase complex 1 (TORC1) activity. Genetic studies have shown the tuberous sclerosis tumor suppressors TSC1/2 and the REDD1 protein to be essential for hypoxia regulation of TORC1 activity in Drosophila and in mammalian cells. The molecular mechanism and physiologic significance of this effect of hypoxia remain unknown. Here, we demonstrate that hypoxia and REDD1 suppress… CONTINUE READING
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