Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

Abstract

The Hippo signalling pathway plays important roles in animal development, physiology and tumorigenesis. Understanding how the activity of this pathway is regulated by the cellular microenvironment remains a major challenge. Here we elucidate a molecular mechanism by which hypoxia deactivates Hippo signalling. We demonstrate that the E3 ubiquitin ligase… (More)
DOI: 10.1038/ncb3073

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