Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme.

@article{Flynn2008HypoxiaregulatedPE,
  title={Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme.},
  author={Jeannette R. Flynn and Libo Wang and David Lawrence Gillespie and Gregory J. Stoddard and Jason K Reid and Jason Owens and Grant B Ellsworth and Karen L Salzman and Anita Y. Kinney and Randy L. Jensen},
  journal={Cancer},
  year={2008},
  volume={113 5},
  pages={1032-42}
}
BACKGROUND Regions of hypoxia within glioblastoma multiforme (GBM) are common and may influence a tumor's aggressiveness, response to treatment, and the patient's overall survival. In this study, the authors examined 4 markers of hypoxia (hypoxia-inducible factor 1 [HIF-1alpha], glucose transporter 1 [GLUT-1], vascular endothelial growth factor [VEGF], and carbonic anhydrase 9 [CA IX]), cellular proliferation and microvascular density (MVD) indices, extent of surgical resection, and… CONTINUE READING

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Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007

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