Hypoxia-regulated overexpression of soluble VEGFR2 controls angiogenesis and inhibits tumor growth.

  title={Hypoxia-regulated overexpression of soluble VEGFR2 controls angiogenesis and inhibits tumor growth.},
  author={Guillaume Collet and Nathalie Lamerant-Fayel and Magdalena Tertil and Bouchra El Hafny-Rahbi and Jacek Stepniewski and Alan Guichard and Alexandra Foucault-Collet and Krzysztof Klimkiewicz and St{\'e}phane P{\`e}toud and Agata Matejuk and Catherine Grillon and Alicja J{\'o}zkowicz and Jozef Dulak and Claudine Kieda},
  journal={Molecular cancer therapeutics},
  volume={13 1},
VEGFs are found at high levels in hypoxic tumors. As major components directing pathologic neovascularization, they regulate stromal reactions. Consequently, novel strategies targeting and inhibiting VEGF overproduction upon hypoxia offer considerable potential for modern anticancer therapies controlling rather than destroying tumor angiogenesis. Here, we report the design of a vector expressing the soluble form of VEGF receptor-2 (sVEGFR2) driven by a hypoxia-responsive element (HRE)-regulated… CONTINUE READING
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