Hypoxia-regulated microRNAs in human cancer

  title={Hypoxia-regulated microRNAs in human cancer},
  author={Guomin Shen and Xiaobo Li and Yong-feng Jia and Gary Anthony Piazza and Yaguang Xi},
  booktitle={Acta Pharmacologica Sinica},
Hypoxia plays an important role in the tumor microenvironment by allowing the development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1 (HIF1) regulates a panel of microRNAs, whereas some of… CONTINUE READING