Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture.


PURPOSE Vascular hypoperfusion, extracellular matrix remodeling and axon loss are pathological characteristics of the glaucomatous optic nerve head. We report a novel study demonstrating transcriptional responses in optic nerve lamina cribrosa (LC) cells exposed to in vitro hypoxic stress. METHODS Primary cultures of human glial fibrillary acid protein… (More)
DOI: 10.1167/iovs.11-6729


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