Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer.

  title={Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer.},
  author={Mette Winther and Line Br\ondum and Brita Singers S\orensen and Catja Foged Wittrup and Trine Tramm and Lene Baeksgaard and Kenneth Francis Hofland and Eva Holtved and Marianne Nordsmark},
  journal={Anticancer research},
  volume={36 2},
BACKGROUND/AIM The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). MATERIALS AND METHODS microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. RESULTS Expression… CONTINUE READING
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