Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma.

@article{Du2014HypoxiaPV,
  title={Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma.},
  author={Jing Du and Baocun Sun and Xiulan Zhao and Qiang Gu and Xueyi Dong and Jing Lan Mo and Tao Sun and Junyan Wang and Ran Sun and Yanrong Liu},
  journal={Gynecologic oncology},
  year={2014},
  volume={133 3},
  pages={
          575-83
        }
}
OBJECTIVES The functions of hypoxia and subsequent hypoxia-inducible factor-1α (HIF-1α) activation in vasculogenic mimicry (VM) are currently unclear. This study aimed to investigate the effects of hypoxia on VM formation in ovarian cancer, and explore the possible mechanism involved. METHODS The expression levels of HIF-1α, E-cadherin, vimentin, Twist1, Slug, and VE-cadherin proteins were analyzed by immunohistochemistry in 71 specimens of epithelial ovarian cancer. The results were… CONTINUE READING
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