Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.

@article{Lafont2008HypoxiaPT,
  title={Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.},
  author={J{\'e}r{\^o}me E Lafont and Sonia Talma and Christine Hopfgarten and Christopher L Murphy},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 8},
  pages={4778-86}
}
The chondrocyte is solely responsible for synthesis and maintenance of the resilient articular cartilage matrix that gives this load-bearing tissue its mechanical integrity. When the differentiated cell phenotype is lost, the matrix becomes compromised and cartilage function begins to fail. We have recently shown that hypoxia promotes the differentiated phenotype through hypoxia-inducible factor 2alpha (HIF-2alpha)-mediated SOX9 induction of the main matrix genes. However, to date, only a few… CONTINUE READING

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