Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.

@article{Wang2012HypoxiaPL,
  title={Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.},
  author={Yi Wang and Olga Roche and Chaoying Xu and Eduardo H. Moriyama and Pardeep Heir and Jacky Chung and Frederik C Roos and Yonghong Chen and Greg Finak and Michael F. Milosevic and Brian C. Wilson and Bin Tean Teh and Morag Park and Meredith S Irwin and Michael Ohh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 13},
  pages={4892-7}
}
Caveolin-1 (CAV1) is an essential structural constituent of caveolae, specialized lipid raft microdomains on the cell membrane involved in endocytosis and signal transduction, which are inexplicably deregulated and are associated with aggressiveness in numerous cancers. Here we identify CAV1 as a direct transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the formation of caveolae, leading to increased dimerization of EGF receptor within the confined surface… CONTINUE READING
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