Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.

@article{Wise2011HypoxiaPI,
  title={Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.},
  author={David R. Wise and Patrick S. Ward and Jessica E.S. Shay and Justin R. Cross and Joshua J. Gruber and Uma M Sachdeva and Jesse M Platt and Raymond G Dematteo and M Celeste Simon and Craig B Thompson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 49},
  pages={19611-6}
}
Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions, glucose provides the acetyl-CoA that condenses with oxaloacetate to support citrate production. Tricarboxylic acid (TCA) cycle anaplerosis is maintained primarily by glutamine. Here we report that some hypoxic cells are able to maintain cell proliferation despite a profound reduction in glucose-dependent citrate… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS