Hypoxia preconditioning attenuates brain edema associated with kainic acid-induced status epilepticus in rats

@article{Emerson1999HypoxiaPA,
  title={Hypoxia preconditioning attenuates brain edema associated with kainic acid-induced status epilepticus in rats},
  author={Mitchell R. Emerson and Stanley R. Nelson and Fred E. Samson and Thomas L. Pazdernik},
  journal={Brain Research},
  year={1999},
  volume={825},
  pages={189-193}
}
Kainic acid (KA)-induced seizures elicit edema associated with necrosis in susceptible brain regions (e.g., piriform cortex and hippocampal CA1 and CA3 regions). To test the hypothesis that hypoxia preconditioning protects against KA-induced edema formation, adult male rats were exposed to a 9% O2, 91% N2 atmosphere for 8 h. KA (14 mg/kg, i.p.) was administered 1, 3, 7, or 14 days later. Regional analysis of edema indicated that hypoxia exposure attenuated edema formation in piriform and… CONTINUE READING
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