Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways.

@article{Walford2004HypoxiaPN,
  title={Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways.},
  author={Geoffrey A. Walford and Rose-Laure Moussignac and Anne Ward Scribner and Joseph Loscalzo and Jane A. Leopold},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 6},
  pages={4425-32}
}
Nitric oxide (NO*) at low concentrations is cytoprotective for endothelial cells; however, elevated concentrations of NO* (> or =1 micromol/liter), as may be achieved during inflammatory states, can induce apoptosis and cell death. Hypoxia is associated with tissue inflammation and ischemia and, therefore, may modulate the effects of NO* on endothelial function. To examine the influence of hypoxia on NO*-mediated apoptosis, we exposed bovine aortic endothelial cells (BAEC) to (Z)-1-[N-(2… CONTINUE READING