Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring.

@article{Xu2006HypoxiaON,
  title={Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring.},
  author={Yi Xu and Sarah J Williams and Darryl W O'Brien and Sandra T Davidge},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 8},
  pages={1251-3}
}
Intrauterine growth restriction (IUGR) increases the risk of developing adult-onset cardiovascular disease. We hypothesized that IUGR resulting from maternal hypoxia or nutrient restriction during late gestation will produce cardiac remodeling and impair cardiac recovery after ischemia/reperfusion (I/R) in adult male offspring aged 4 or 7 mo. Sprague-Dawley rats were randomized on day 15 of pregnancy to hypoxia (IUGR-H, 12% oxygen), nutrient restriction (IUGR-NR, 40% of control diet) or control… CONTINUE READING

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