Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum

  title={Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum},
  author={Dana Jurkovi{\vc}ov{\'a} and Juraj Kop{\'a}cek and Peter Stefanik and Lucia Kubovcakova and Alexandra Zahradn{\'i}kov{\'a} and Silvia Pastorekov{\'a} and Oľga Kri{\vz}anov{\'a}},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
Hypoxic brain cell injury is a complex process that results from a series of intracellular events. In this work, we tested whether severe hypoxia for 6 h can affect gene expression and protein levels of intracellular calcium channels, ryanodine receptors, and inositol 1,4,5-trisphosphate receptors in mouse cerebellum. In addition, we tested the effect of hypoxia on cerebellar granular cells of rats. We have found that gene expression of types 1 and 2 IP3 receptors is significantly increased… CONTINUE READING


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