Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells.

@article{Jeong2016HypoxiamediatedAF,
  title={Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells.},
  author={J Y Jeong and Sangiliyandi Gurunathan and Min-Hee Kang and Jae Woong Han and Joydeep Das and Yun-Jung Choi and Deug-Nam Kwon and Ssang-Goo Cho and Chankyu Park and Han Geuk Seo and Hyuk Song and Jin-Hoi Kim},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={21688}
}
Solid tumors are frequently associated with resistance to chemotherapy because the fraction of hypoxic tumor cells is substantial. To understand the underlying mechanism of hypoxia on silver nanoparticle (AgNPs)-induced apoptosis, the expression of hypoxia-inducible factor (HIF)-1α, a hallmark of hypoxia, was measured in the presence and absence of AgNPs. The results showed that HIF-1α expression was upregulated after AgNPs treatment under both hypoxic and normoxic conditions. Cell viability… CONTINUE READING
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