Hypoxia maintains and interleukin-3 reduces the pre-colony-forming cell potential of dividing CD34(+) murine bone marrow cells.

@article{Ivanovic2002HypoxiaMA,
  title={Hypoxia maintains and interleukin-3 reduces the pre-colony-forming cell potential of dividing CD34(+) murine bone marrow cells.},
  author={Zoran Ivanovic and Françis Belloc and Jean-Luc Faucher and Maria-Grazia Cipolleschi and Vincent Praloran and Persio Dello Sbarba},
  journal={Experimental hematology},
  year={2002},
  volume={30 1},
  pages={67-73}
}
OBJECTIVE The aim of this study was to determine whether the combination of a sizable generation of colony-forming cells (CFC) with the maintenance of their progenitors (pre-CFC) ensured by incubation in hypoxia is associated with a certain degree of cell cycling, ultimately responsible for "self-renewal" of pre-CFC. The effects of interleukin-3 (IL-3) on the cycling and CFC-generation potential of pre-CFC also was investigated. MATERIALS AND METHODS In severely hypoxic (0.9% O(2)) murine… CONTINUE READING

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